An influenza A virus vaccine based on an M2e‑modified alphavirus

Collection Location Koleksi E-book & E-Journal Perpustakaan Pusat Unila
Edition Vol. 163, Issue 2
Call Number
ISBN/ISSN 14328798
Author(s) Krishnavajhala, Haritha Ramya
Williams, Jacqueline
Heidner, Hans
Subject(s) Biomedicine
Classification NONE
Series Title
GMD E-Journal
Language English
Publisher Springer
Publishing Year 2018
Publishing Place Switzerland
Abstract/Notes Abstract The 23-residue external domain of the influenza
A virus M2 protein (M2e) has significant potential as a vaccine
antigen. Here, we describe the construction and characterization
of an M2e-modified Sindbis virus designated
E2S1-M2e. E2S1-M2e virions contain M2e as an N-terminal
extension of the E2 glycoprotein and therefore express 240
copies of the M2e peptide on their surface. The E2S1-M2e
virus expressed M2e in an accessible and immunogenic form
and induced M2e-specific antibodies when administered to
mice. Mice that received an intranasal vaccination with
E2S1-M2e were protected against a lethal challenge with a
virulent, mouse-adapted strain of influenza A virus.
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