Characterization of the neuraminidase genes from human influenza A viruses circulating in Iran from 2010 to 2015

Collection Location Koleksi E-book & E-Journal Perpustakaan Pusat Unila
Edition Vol. 163, Issue 2
Call Number
ISBN/ISSN 14328798
Author(s) Moasser, Elham...[et al.]
Subject(s) Biomedicine
Classification NONE
Series Title
GMD E-Journal
Language English
Publisher Springer
Publishing Year 2018
Publishing Place Switzerland
Collation
Abstract/Notes Abstract
Background Characterization of influenza viruses is critical
for detection of new emerging variants. Herein, we
analyzed the genetic diversity and drug susceptibility of
the neuraminidase gene (NAs) expressed by influenza A/
H1N1pdm09 and A/H3N2 viruses circulating in Iran from
2010 to 2015.
Methods We genetically analyzed the NAs of 38 influenza
A/H1N1pdm09 and 35 A/H3N2 isolates.
Results The Iranian A/H1N1pdm09 viruses belonged
to seven genogroups/subgenogroups, with the dominant
groups being genogroups 6B and 6C. The A/H3N2 isolates
fell into six gneogroups/subgenogroups, with the
dominant genogroups being 3C and 3C.2a. The most common mutations detected among the A/H1N1pdm09
viruses included N44S, V106I, N200S, and N248D. All
H1N1pdm09 viruses were genetically susceptible to the
NAIs. However, one A/H1N1pdm09 virus from the 2013–
2014 season possessed an NA-S247N mutation, which
reduces the susceptibility to oseltamivir. In case of H3N2,
none of the analyzed Iranian strains carried a substitution
that might affect its susceptibility to NAIs.
Conclusion The ongoing evolution of influenza viruses and
the detect of influenza viruses with reduced susceptibility
to NAIs warrants continuous monitoring of the circulating
strains.
Keywords Influenza · A/H1N1pdm09 · A/H3N2 ·
Molecular genetic analysis · Antiviral resistance · Iran
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