Vitamin D supplementation to persistent carriers of MRSA—a randomized and placebo-controlled clinical trial

Collection Location Koleksi E-book & E-Journal Perpustakaan Pusat Unila
Edition Vol. 37, Issue 9
Call Number
ISBN/ISSN 1435-4373
Author(s) Bergman, Linda Björkhem...[et al.]
Subject(s) Biomedicine
Classification NONE
Series Title
GMD E-Journal
Language English
Publisher Springer
Publishing Year 2018
Publishing Place Switzerland
Abstract/Notes Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is resistant to all beta-lactamantibiotics and can cause severe infections that
are difficult to treat. Eradication strategies with conventional antibiotics are not always effective and alternative approaches are
warranted.Here, we tested the hypothesis that daily supplementation with vitamin D for 12 monthswould reduceMRSA carriage
rates among a group of persistent carriers. This was a double-blind, placebo-controlled randomized trial with n = 65 persistent
MRSA carriers with 25-hydroxy vitamin D3 (25OHD) < 75 nmol/L, who were followed up with bacterial cultures at baseline and
every 3 months for 1 year. The primary endpoint was the decline in MRSA positivity during the study period. The study was
conducted in two MRSA outpatient clinics at the Karolinska University Hospital, Stockholm, Sweden. In total, n = 65 persistent
MRSA carriers were randomized and n = 3 were lost to follow-up. Only patients deficient in vitamin D (< 75 nmol/L) were
included. Vitamin D (4000 IU) or placebo/day was administered for 12 months. The decline in MRSA positivity was equal in the
vitamin D and placebo group during the study period (OR, 1.00; 95% CI, 0.97–1.03; p = 0.928) and approximately 40% in both
groups were MRSA-negative after 12 months. The vitamin D group produced 103 positive cultures out of 318 cultures (32.4%)
from nose, throat, and perineum over the study period, whereas the placebo group produced 135/393 positive cultures (34.0%)
(Fisher’s exact test, p = 0.94). Vitamin D supplementation did not influence MRSA carriage. Thus, available data does not
support vitamin D supplementation to persistent MRSA carriers.
Trial registration:; NCT02178488.
Keywords Methicillin-resistant S. aureus (MRSA) . Vitamin D . Clinical trial . Immunity
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