Clonal diversity of Ureaplasma species and its relationship with oligozoospermia and semen quality in Chinese infertile males

Collection Location Koleksi E-book & E-Journal Perpustakaan Pusat Unila
Edition Vol. 37, Issue. 10
Call Number
ISBN/ISSN 1435-4373
Author(s) Ting Yang...[et al.]
Subject(s) Biomedicine
Classification NONE
Series Title
GMD E-Journal
Language English
Publisher Springer
Publishing Year 2018
Publishing Place Switzerland
Abstract/Notes Abstract
Whether Ureaplasma spp. are a causative agent of male infertility remains controversial. Previous studies concerning
Ureaplasma spp. and male infertility have been confined to the species level of Ureaplasma. Currently, an expanded multilocus
sequence typing (eMLST) scheme has been established with high discriminatory power. The aim of this study was to use eMLST
to explore the distribution of Ureaplasma spp. and to analyze its role in oligozoospermia and semen quality. A total of 480 semen
samples were obtained from Chinese infertile males. The associations between Ureaplasma spp. with oligozoospermia and
semen characteristics were further evaluated. Phylogenetic analysis revealed that 102 Ureaplasma spp. could be separated into
two clusters and seven sub-groups.Within cluster I (U. parvum), eST16 and eST41 were the most frequent clones. For cluster II
(U. urealyticum), eST82 and eST147 were the most prevalent clones. Sub-groups A and C belonging to cluster I and sub-group 1
belonging to cluster II showed an association with oligozoospermia, in contrast with the Ureaplasma spp. negative group (P <
0.05). Compared with the negative group, semen motility decreased in sub-group 2, especially for non-progressive motility (P <
0.05). These results indicated that sub-groups A and C belonging to cluster I (U. parvum) and sub-group 1 belonging to cluster II
(U. urealyticum) were shown to be associated with oligozoospermia. Sub-group 2 belonging to cluster II may have the ability to
impair semen motility, especially for non-progressive motility.
Keywords Ureaplasma spp. . eMLST . Clonality . Oligozoospermia . Semen quality
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