Genetic approach towards a vaccine against malaria

Collection Location Koleksi E-book & E-Journal Perpustakaan Pusat Unila
Edition Vol. 37, Issue. 10
Call Number
ISBN/ISSN 1435-4373
Author(s) Garrido-Cardenas, Jose Antonio
Mesa-Valle, ConcepciOn
Manzano-Agugliaro, Francisco
Subject(s) Biomedicine
Classification NONE
Series Title
GMD E-Journal
Language English
Publisher Springer
Publishing Year 2018
Publishing Place Switzerland
Abstract/Notes Abstract
Malaria is a major concern for international health authorities. Millions of people contract it every year in the world due to a
parasite of the Plasmodium genus. Due to the complexity of the parasite biology and genetics, there is currently no vaccine
against the disease. However, due to the great resistance both to the medicines and to the insecticides used to combat the disease,
it has become essential to obtain a vaccine as the necessary tool to prevent transmission and eliminate the disease. The
bibliometric data indicate that interest in vaccines has been growing steadily since the 1980s. But nowadays, a powerful tool
is used: the Plasmodium genome. This allows us to improve the fight against the disease. Knowing the sequences of the genes
that favor the appearance of drug resistance, or those that encode for proteins with greater antigenic response, is a tool that can
become fundamental. This article reviews the state of the art on vaccines and genetics, in the fight against malaria, and analyzes
the fixed photo that the worldwide research on the disease poses.
Keywords Malaria . Genes . Vaccine . Plasmodium . Worldwide
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