Prevalence and risk factors of post chikungunya rheumatic musculoskeletal disorders: a prospective follow-up study in French Guiana

Collection Location Koleksi E-book & E-Journal Perpustakaan Pusat Unila
Edition Vol. 37, Issue. 10
Call Number
ISBN/ISSN 1435-4373
Author(s) Bonifay, Timothée...[et al.]
Subject(s) Biomedicine
Classification NONE
Series Title
GMD E-Journal
Language English
Publisher Springer
Publishing Year 2018
Publishing Place Switzerland
Abstract/Notes Abstract
The estimated seroprevalence in the general population after chikungunya virus (CHIKV) epidemics ranged from 38 to 63%.
Despite a low case fatality, subacute and chronic rheumatic forms of CHIKVinfection generate significant morbidity and have a
socioeconomic impact. The objective of the study was to estimate the prevalence of chronic post-CHIKV rheumatic or musculoskeletal
pain (pCHIK-RMSP) at 3 and 6 months after the initial symptoms. An observational study was conducted at Cayenne
General Hospital in French Guiana between April 1 and June 30, 2014. All patients seen for CHIKVinfection confirmed by RTPCR
were prospectively included. Pregnant women and children under 15 were excluded from the study. All patients were called
by phone at 3 and 6 months to enquire about the presence of pCHIK-RMSP. Out of a total of 254 eligible patients, 168 were
selected. The mean age was 45.3 years (SD ± 1.4 yo) and the sex ratio (M/F) was 0.75. No death was reported. At 3 months,
40.2% (95% CI 31.1–49.3) of patients (n = 45/112) had pCHIK-RMSP and 31.3% (95% CI 22.2–40.4) of patients (n = 31/99) at
6 months. The median time of end to pain was 2 weeks after the date of onset of signs. The present study provides succinct but
informative data about pCHIK-RMSP, which represents the real burden of the disease. There are few studies on that subject in the
Amazonian region, but our study shows a lower impact than in the Indian Ocean islands where the population is older.
Keywords Chikungunya . Chronical forms . French Guiana . Persistent joint pain . Cross sectional study
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