Related carbapenemase-producing Klebsiella isolates detected in both a hospital and associated aquatic environment in Sweden

Collection Location Koleksi E-book & E-Journal Perpustakaan Pusat Unila
Edition Vol. 37, Issue. 12
Call Number
ISBN/ISSN 1435-4373
Author(s) Khan, Faisal Ahmad...[et al.]
Subject(s) Biomedicine
Classification NONE
Series Title
GMD E-Journal
Language English
Publisher Springer
Publishing Year 2018
Publishing Place Switzerland
Abstract/Notes Abstract
Carbapenem antibiotics are one of the last-resort agents against multidrug-resistant (MDR) bacteria. The occurrence of
carbapenemase-producing Enterobacteriaceae (CPE) in wastewater and aquatic environments is an indication of MDR bacteria
in the community. This study evaluated CPE in aquatic environments and compared themto the local hospital isolates in Sweden.
Phenotypic and genotypic analyses of antibiotic resistance of environmental and clinical CPE were performed. The relatedness of
the isolates and possible clonal dissemination was evaluated using phylogenetic and phyloproteomic analysis. Klebsiella oxytoca
carrying carbapenemase genes (blaVIM-1, blaIMP-29) were isolated from wastewater and the recipient river, while K. oxytoca
(blaVIM-1) and Klebsiella pneumoniae (blaVIM-1, blaOXA-48, blaNDM-1, blaKPC-3) were isolated from patients at the local clinics or
hospital. The K. oxytoca classified as sequence type 172 (ST172) isolated from the river was genotypically related to two clinical
isolates recovered from patients. The similarity between environmental and clinical isolates suggests the dispersion of
blaVIM-1 producing K. oxytoca ST172 from hospital to aquatic environment and the likelihood of its presence in the
community. This is the first report of CPE in aquatic environments in Sweden; therefore, surveillance of aquatic and
hospital environments for CPE in other urban areas is important to determine the major transfer routes in order to formulate
strategies to prevent the spread of MDR bacteria.
Keywords Antimicrobial resistance . Klebsiella pneumoniae . Klebsiella oxytoca . Multidrug resistance . Extended spectrum
beta-lactamase . Carbapenemase-producing Enterobacteriaceae
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