Human polyomavirus KI, WU, BK, and JC in healthy volunteers
|Collection Location||Koleksi E-book & E-Journal Perpustakaan Pusat Unila|
|Edition||Vol. 38, Issue 1|
|Author(s)||Pena, Giselle P. A...[et al.]
Despite the growing importance of infections caused by the human polyomaviruses (HPyVs), information about their transmission,
pathogenesis, and epidemiology is scarce. The objective of this work was to evaluate the excretion and distribution of HPyV
(HPyV1-HPyV4 [former BKPyV, JCPyV, KIPyV, and WUPyV, respectively]) among asymptomatic individuals from different
geographic regions in Brazil, in order to verify the existence of distinct epidemiologic patterns among the Brazilian population.
Saliva samples from 889 healthy volunteers living in nine locations in Brazil were analyzed by real-time polymerase chain
reaction (PCR) to detect HPyV1–4. Among 889 participants, 346 (39%) had evidence of infection with one or more HPyV
species: 127 (14.3%) had HPyV1 only; 70 (7.9%) had HPyV3 only; 60 (6.7%) had HPyV4 only, and 25 (2.8%) had HPyV2 only.
Coinfections were detected in 64 participants (7.3%). Although HPyVexcretion was detected in samples from all locations, the
frequency and distribution of viral species varied significantly. The epidemiologic findings presented demonstrate that the four
HPyV species studied are circulating in five geographic regions of Brazil. Salivary excretion of these viruses appears common
among healthy Brazilians. The distribution of viral species varies considerably between regions as well as within regions.
Keywords Polyomaviruses . Saliva . BKPyV . JCPyV . KIPyV .WUPyV
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