The downside of antimicrobial agents for wound healing

Collection Location Koleksi E-book & E-Journal Perpustakaan Pusat Unila
Edition Vol. 38, Issue 1
Call Number
ISBN/ISSN 1435-4373
Author(s) Punjataewakupt, Apirujee
Napavichayanun, Supamas
Aramwit, Pornanong
Subject(s) Biomedicine
Classification NONE
Series Title
GMD E-Book
Language English
Publisher Springer
Publishing Year 2019
Publishing Place Switzerland
Abstract/Notes Abstract
The use of topical antimicrobials is beneficial for infection control in wound care because wound infection is the major cause of
delayed healing. The advantages of topical over systemic antimicrobials include a higher concentration at the target site, fewer
systemic adverse effects, and a lower incidence of antimicrobial resistance. Nowadays, topical antimicrobials are divided into
three groups: disinfectants, antiseptics, and antibiotics. Only antiseptics and antibiotics can be applied to living skin; therefore,
this review will focus only on these groups. The advantages of each topical antimicrobial are well established; however, their
disadvantages remain prominent. It is widely known that antiseptics show higher cytotoxicity and a broader spectrum of activity
than antibiotics, whereas antibiotics show a higher probability of bacterial resistance development. However, there are still many
adverse effects, resulting from each topical antimicrobial. This review aims to summarize the possible adverse effects of
commonly used antiseptics (biguanide, silver, iodine, chlorine compounds, and other antiseptics), antibiotics (bacitracin,
mafenide, mupirocin, neomycin, and silver sulfadiazine), and natural antimicrobials (curcumin and honey). Moreover, the
antimicrobials that should be avoided in particular populations are also summarized in this review in order to increase awareness
for antimicrobial selection in those populations.
Keywords Topical antimicrobials . Wounds . Adverse effect . Toxicity
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