Clinical spectrum of Lyme disease

Collection Location Koleksi E-book & E-Journal Perpustakaan Pusat Unila
Edition Vol. 38, Issue 2
Call Number
ISBN/ISSN 1435-4373
Author(s) Cardenas, Jesus Alberto...[et al.]
Subject(s) Biomedicine
Classification NONE
Series Title
GMD E-Journal
Language English
Publisher Springer
Publishing Year 2019
Publishing Place Switzerland
Abstract/Notes Abstract
Lyme disease (borreliosis) is one of the most common vector-borne diseases worldwide. Its incidence and geographic expansion has
been steadily increasing in the last decades. Lyme disease is caused by Borrelia burgdorferi sensu lato, a heterogeneous group of
which three genospecies have been systematically associated to Lyme disease: B. burgdorferi sensu stricto Borrelia afzelii and
Borrelia garinii. Geographical distribution and clinical manifestations vary according to the species involved. Lyme disease clinical
manifestations may be divided into three stages. Early localized stage is characterized by erythema migrans in the tick bite site. Early
disseminated stage may present multiple erythema migrans lesions, borrelial lymphocytoma, lyme neuroborreliosis, carditis, or
arthritis. The late disseminated stage manifests with acordermatitis chronica atrophicans, lyme arthritis, and neurological symptoms.
Diagnosis is challenging due to the varied clinical manifestations it may present and usually involves a two-step serological
approach. In the current review, we present a thorough revision of the clinical manifestations Lyme disease may present.
Additionally, history, microbiology, diagnosis, post-treatment Lyme disease syndrome, treatment, and prognosis are discussed.
Keywords Lyme disease . Borrelia burgdorferi . Tick-borne diseases . Ixodes . Erythema migrans . Lyme neuroborreliosis
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