Radiologic types of Mycobacterium xenopi pulmonary disease: different patients with similar short-term outcomes
|Collection Location||Koleksi E-book & E-Journal Perpustakaan Pusat Unila|
|Edition||Vol. 38, Issue 2|
Brode, Sarah K.
Marras, Theodore K.
Mycobacterium xenopi pulmonary disease (Mxe-PD) is common among nontuberculous mycobacterial infections in Europe and
Canada. Associations between radiological pattern and clinical features and outcomes are inadequately studied in Mxe-PD. We
sought to investigate clinical characteristics and outcomes according to the dominant radiological pattern among patients with
Mxe-PD. We retrospectively studied patients with Mxe-PD seen in our clinic, categorizing their predominant CT pattern as
nodular bronchiectasis, fibrocavitary, or unclassifiable, and compared clinical characteristics, treatment, and outcomes between
radiologic groups. Of 94 patients with Mxe-PD, CT patterns comprised nodular bronchiectasis (40/94, 42.6%), fibrocavitary (37/
94, 39.4%), and unclassifiable (17/94, 18.1%). Compared with fibrocavitation, patients with nodular bronchiectasis were female
dominant, less often had COPD, less often had AFB smear-positive sputum, and more frequently had co-isolation of
Pseudomonas. Patients with nodular bronchiectasis were less often treated (65% versus 91.9%) and when treated, they received
fewer anti-mycobacterial drugs (on average 3 versus 4). Outcomes did not differ significantly by radiological pattern. Nodular
bronchiectasis was common among Mxe-PD patients in our clinic. Compared with fibrocavitary disease, patients with nodular
bronchiectasis had features suggestive of milder disease and were less often treated. Among treated patients, outcomes did not
differ by radiologic pattern.
Keywords Mycobacterium xenopi . Nontuberculous mycobacteria . Chest CT . Nodular bronchiectasis
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