Assessment of the tau protein concentration in patients with tick-borne encephalitis

Collection Location Koleksi E-book & E-Journal Perpustakaan Pusat Unila
Edition Vol. 38, Issue 3
Call Number
ISBN/ISSN 1435-4373
Author(s) Czupryna, Piotr...[et al.]
Subject(s) Biomedicine
Classification NONE
Series Title
GMD E-Journal
Language English
Publisher Springer
Publishing Year 2019
Publishing Place Switzerland
Abstract/Notes There have been suggestions that tick-borne encephalitis (TBE) may cause neurodenenerative changes in the brain. The aim of
this study was the assessment of the tau protein concentration in cerebrospinal fluid (CSF) of patients with different clinical forms
of TBE. The concentration of tau protein in CSF was determined using Fujirebio tests (Ghent, Belgium) in 35 patients with TBE:
group I—patients with meningitis (n = 16); group II—patients with meningoencephalitis (n = 19). None of the patients reported
any neurodegenerative disorder that could affect the results of the study. The control group (CG) consisted of 10 patients in whom
inflammatory process in central nervous system was excluded. Tau protein concentration in CSF before treatment did not differ
significantly between the examined groups, while its concentration was significantly higher in encephalitis group than in CG after
14 days of treatment. Significant increase in tau protein concentration after treatment was observed in both examined groups. The
comparison between the group of patients who fully recovered and patients who presented with persistent symptoms on discharge
showed significant differences in tau protein concentration before and after treatment. ROC curve analysis indicates that CSF tau
protein concentration before treatment may predict complicated course of the disease with 90.9%specificity and 80%sensitivity,
while after treatment, specificity became 72.7%and 71.4%for sensitivity. Correlation analysis showed that in TBE patients (both
meningoencephalitis and meningitis groups), CSF pleocytosis before treatment correlated negatively with tau protein concentration
in CSF. (1) Neurodegeneration process is present in TBE encephalitis. (2) Tau protein concentration may be used as a
predictor of complicated course of TBE.
Keywords Tick-borne encephalitis . Tau . Neurodegeneration
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