Limited awareness of the effective timing of HIV post-exposure prophylaxis among people with high-risk exposure to HIV

Collection Location Koleksi E-book & E-Journal Perpustakaan Pusat Unila
Edition Vol. 38, Issue 4
Call Number
ISBN/ISSN 1435-4373
Author(s) Leshin, Daniel...[et al.]
Subject(s) Biomedicine
Classification NONE
Series Title
GMD E-Journal
Language English
Publisher Springer
Publishing Year 2019
Publishing Place Switzerland
Abstract/Notes Abstract
The effectiveness of post-exposure prophylaxis (PEP), a major strategy in the battle against HIV, depends on awareness of this
modality and its proper timing among high-risk groups. While general awareness of PEP is improving, recently estimated to be
36–47% among men who have sex with men (MSM), PEP implementation remains disappointingly low and may be driven by
limited awareness of effective PEP timing window. The level of detailed understanding of PEP timing and effectiveness among
populations at risk has not been prospectively assessed to date. We prospectively evaluated, for the first time, actionable
awareness regarding effective timing of PEP among a large cohort of individuals tested for HIV following unprotected sexual
intercourse. Four hundred participants were assessed between December 2014 and February 2016. Overall awareness of the
option of PEP was 60% and was significantly higher among male members of the LGBTQ community (75·5% as compared to
52·6% among heterosexual males) and those undergoing past HIV testing (67·1%). However, only 24% of individuals at risk
were aware as to the proper timing of effective PEP treatment, thereby leading, in the majority of cases, to missing the window of
opportunity for PEP treatment. This study highlights the lack of knowledge as to the specific requirements needed for effective
PEP timing. Expanded advertising, better targeting of the heterosexual population, training of family physicians in the field of
gender, sexuality, and LGBTQ medicine, may improve effective PEP availability, thereby reducing HIV transmission.
Keywords HIV . Post-exposure prophylaxis .Awareness
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